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N-Methylated pomalidomide

CAT: 0804-HY-W586822-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W586822-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
N-methylated pomalidomide (Pomalidomide-methyl), a derivative of Pomalidomide , is a cereblon (CRBN) ligand. N-methylated pomalidomide is unable to recruit CRBN that can be used as a negative control for Pomalidomide. N-methylated pomalidomide can be used to synthesize PROTAC[1].
CAS Number
1352827-50-9
Product Name Alternative
Pomalidomide-methyl
UNSPSC
12352005
Hazard Statement
H302, H312, H332, H361
Target
Ligands for E3 Ligase
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
97.86
Smiles
O=C1C2=C(C(N1C3C(N(C)C(CC3)=O)=O)=O)C(N)=CC=C2
Molecular Formula
C14H13N3O4
Molecular Weight
287.27
Precautions
H302, H312, H332, H361
References & Citations
[1]Yokoo H, et al. Development of a Hematopoietic Prostaglandin D Synthase-Degradation Inducer. ACS Med Chem Lett. 2021 Jan 14;12 (2) :236-241.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon

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