N-Methylated pomalidomide

• Description :

  N-methylated pomalidomide (Pomalidomide-methyl), a derivative of Pomalidomide (HY-10984), is a cereblon (CRBN) ligand. N-methylated pomalidomide is unable to recruit CRBN that can be used as a negative control for Pomalidomide. N-methylated pomalidomide can be used to synthesize PROTAC[1].

• Product Name Alternative :

  Pomalidomide-methyl

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H312, H332, H361

• Target :

  Ligands for E3 Ligase

• Related Pathways :

  PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Purity :

  97.86

• Smiles :

  O=C1C2=C(C(N1C3C(N(C)C(CC3)=O)=O)=O)C(N)=CC=C2

• Molecular Formula :

  C14H13N3O4

• Molecular Weight :

  287.27

• Precautions :

  H302, H312, H332, H361

• References & Citations :

  [1]Yokoo H, et al. Development of a Hematopoietic Prostaglandin D Synthase-Degradation Inducer. ACS Med Chem Lett. 2021 Jan 14;12 (2) :236-241.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Cereblon

• CAS Number :

  [1352827-50-9]