Pomalidomide-d4

• Description:

  Pomalidomide-d4 is the deuterium labeled Pomalidomide. Pomalidomide, the third-generation immunomodulatory agent, acts as molecular glue. Pomalidomide interacts with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors<

• Product Name Alternative:

  CC-4047-d4

• UNSPSC:

  12352005

• Hazard Statement:

  H360

• Target:

  Apoptosis; Isotope-Labeled Compounds; Ligands for E3 Ligase; Molecular Glues

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Apoptosis; Others; PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Purity:

  96.38

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1N(C2C(NC(C([2H])([2H])C2([2H])[2H])=O)=O)C(C3=C(N)C=CC=C31)=O

• Molecular Formula:

  C13H7D4N3O4

• Molecular Weight:

  277.27

• Precautions:

  H360

• References & Citations:

  [1]Zhu YX, et al. Molecular mechanism of action of the immune-modulatory drugs, thalidomide, lenalidomide and pomalidomide in multiple myeloma. Leuk Lymphoma. 2013 Apr;54 (4) :683-7.; Hernandez-Ilizaliturri FJ1, et al. Immunomodulatory drug CC-5013 or CC-4047 a|[2]Hernandez-Ilizaliturri FJ, et al. Immunomodulatory drug CC-5013 or CC-4047 and rituximab enhance antitumor activity in a severe combined immunodeficient mouse lymphoma model. Clin Cancer Res. 2005 Aug 15;11 (16) :5984-92.|[3]Yuan Xiao Zhu, et al. Molecular mechanism of action of the immune-modulatory drugs, thalidomide, lenalidomide and pomalidomide in multiple myeloma. Leuk Lymphoma. 2013 Apr;54 (4) :683-7.; Hernandez-Ilizaliturri FJ1

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• Isoform:

  Cereblon

• CAS Number:

  [1416575-78-4]