Pomalidomide-d4

• Description :

  Pomalidomide-d4 is the deuterium labeled Pomalidomide. Pomalidomide, the third-generation immunomodulatory agent, acts as molecular glue. Pomalidomide interacts with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors<

• Product Name Alternative :

  CC-4047-d4

• UNSPSC :

  12352005

• Hazard Statement :

  H360

• Target :

  Apoptosis; Isotope-Labeled Compounds; Ligands for E3 Ligase; Molecular Glues

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Apoptosis; Others; PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Purity :

  96.38

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1N(C2C(NC(C([2H])([2H])C2([2H])[2H])=O)=O)C(C3=C(N)C=CC=C31)=O

• Molecular Formula :

  C13H7D4N3O4

• Molecular Weight :

  277.27

• Precautions :

  H360

• References & Citations :

  [1]Zhu YX, et al. Molecular mechanism of action of the immune-modulatory drugs, thalidomide, lenalidomide and pomalidomide in multiple myeloma. Leuk Lymphoma. 2013 Apr;54 (4) :683-7.; Hernandez-Ilizaliturri FJ1, et al. Immunomodulatory drug CC-5013 or CC-4047 a|[2]Hernandez-Ilizaliturri FJ, et al. Immunomodulatory drug CC-5013 or CC-4047 and rituximab enhance antitumor activity in a severe combined immunodeficient mouse lymphoma model. Clin Cancer Res. 2005 Aug 15;11 (16) :5984-92.|[3]Yuan Xiao Zhu, et al. Molecular mechanism of action of the immune-modulatory drugs, thalidomide, lenalidomide and pomalidomide in multiple myeloma. Leuk Lymphoma. 2013 Apr;54 (4) :683-7.; Hernandez-Ilizaliturri FJ1

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• Isoform :

  Cereblon

• CAS Number :

  [1416575-78-4]