Pomalidomide (Standard)

CAT: 0804-HY-10984R-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-10984R-01Size:5 mg
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Description
Pomalidomide (Standard) is the analytical standard of Pomalidomide. This product is intended for research and analytical applications. Pomalidomide, the third-generation immunomodulatory agent, acts as molecular glue. Pomalidomide interacts with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors.
CAS Number
[19171-19-8]
Product Name Alternative
CC-4047 (Standard)
UNSPSC
12352005
Hazard Statement
H360
Target
Apoptosis; Ligands for E3 Ligase; Molecular Glues; Reference Standards
Type
Reference Standards
Related Pathways
Apoptosis; Others; PROTAC
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pomalidomide-standard.html
Purity
99.72
Smiles
O=C1N(C(C2=C1C=CC=C2N)=O)C(C(N3)=O)CCC3=O
Molecular Formula
C13H11N3O4
Molecular Weight
273.24
Precautions
H360
References & Citations
[1]Zhu YX, et al. Molecular mechanism of action of the immune-modulatory drugs, thalidomide, lenalidomide and pomalidomide in multiple myeloma. Leuk Lymphoma. 2013 Apr;54 (4) :683-7.|[2]Hernandez-Ilizaliturri FJ1, et al. Immunomodulatory drug CC-5013 or CC-4047 and rituximab enhance antitumor activity in a severe combined immunodeficient mouse lymphoma model. Clin Cancer Res. 2005 Aug 15;11 (16) :5984-92.|[3]Schafer PH, et al. Enhancement of cytokine production and AP-1 transcriptional activity in T cells by thalidomide-related immunomodulatory drugs. J Pharmacol Exp Ther. 2003 Jun;305 (3) :1222-32.|[4]Li Z, et al. Pomalidomide shows significant therapeutic activity against CNS lymphoma with a major impact on the tumor microenvironment in murine models. PLoS One. 2013 Aug 5;8 (8) :e71754.|[5]Lu J, et al. Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4. Chem Biol. 2015 Jun 18;22 (6) :755-63.|[6]Liu D, et al. Tumour necrosis factor-α inhibits hepatic lipid deposition through GSK-3β/β-catenin signaling in juvenile turbot (Scophthalmus maximus L.) . Gen Comp Endocrinol. 2016 Mar 1;228:1-8.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards
Isoform
Cereblon

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