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Rabbit Polyclonal Antibody to BRCA1

CAT: 1725-P23574-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:1725-P23574-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator (PubMed:20160719) .
Product Name Alternative
BRCA1; RNF53; Breast cancer type 1 susceptibility protein; RING finger protein 53
Swiss Prot
P38398
Host
Rabbit
Reactivity
Human, Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human BRCA1. AA range:1391-1440
Clonality
Polyclonal
Applications
WB, IHC, IF
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Formulation
Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol.
Antibody Type
Primary antibody
Protein Name
BRCA1
Bands Size
Calculated MW: 208 kDa; Observed MW: 208 kDa

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