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Rabbit Polyclonal Antibody to BRCA2

CAT: 1725-P44674-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:1725-P44674-01Size:50 µL
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Description
Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA) . Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication.
Product Name Alternative
Breast cancer type 2 susceptibility protein
Swiss Prot
P51587
Host
Rabbit
Reactivity
Mouse, Rat
Immunogen
Synthesized peptide derived from N-terminal of human BRCA2.
Clonality
Polyclonal
Applications
WB, IF
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Formulation
Purified antibody in PBS with 0.05% sodium azide.
Antibody Type
Primary antibody
Protein Name
BRCA2
Bands Size
385kd

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