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Rabbit Polyclonal Antibody to BRCA2

CAT: 1725-P10727-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:1725-P10727-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.
Product Name Alternative
FAD, FACD, FAD1, GLM3, BRCC2, FANCB, FANCD, PNCA2, FANCD1, BROVCA2
Swiss Prot
P51587
Host
Rabbit
Reactivity
Human
Immunogen
Synthetic peptide of human BRCA2
Clonality
Polyclonal
Applications
IHC
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Formulation
Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.
Antibody Type
Primary antibody
Protein Name
BRCA2

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