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4-MDM

CAT: 0804-HY-W097753-02Size: 250 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W097753-02Size:250 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
4-MDM (4-Methoxydiphenylmethane) is an orally active anti-inflammatory compound that selectively enhances the Leukotriene A4 Hydrolase (LTA4H) aminopeptidase enzyme activity. 4-MDM reduces the neutrophil recruitment in the lung by enhancing the degradation of proline-glycine-proline by LTA4H, thereby reducing inflammation, and does not affect the epoxy-hydrolase activity of LTA4H. 4-MDM can be used for research on lung diseases[1].
CAS Number
834-14-0
Product Name Alternative
4-Methoxydiphenylmethane
UNSPSC
12352005
Hazard Statement
H315, H318, H400
Target
Aminopeptidase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Purity
99.64
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
COC1=CC=C(C=C1)CC2=CC=CC=C2
Molecular Formula
C14H14O
Molecular Weight
198.26
Precautions
H315, H318, H400
References & Citations
[1]Farhan N, et al. Ultrapressure liquid chromatography-tandem mass spectrometry assay using atmospheric pressure photoionization (UPLC-APPI-MS/MS) for quantification of 4-methoxydiphenylmethane in pharmacokinetic evaluation. J Pharm Biomed Anal. 2016 Sep 5;128:46-52.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

4-Methoxydiphenylmethane

augments activity of leukotriene A(4) hydrolase

CAS Number834-14-0
PubChem CID13264
IUPAC Name1-benzyl-4-methoxybenzene
Molecular FormulaC14H14O
Molecular Weight198.26
XLogP3.8
Topological Polar Surface Area9.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count1
Rotatable Bond Count3
Heavy Atom Count15
Formal Charge0
Complexity164
SMILES
COC1=CC=C(C=C1)CC2=CC=CC=C2
InChI
InChI=1S/C14H14O/c1-15-14-9-7-13(8-10-14)11-12-5-3-2-4-6-12/h2-10H,11H2,1H3
InChIKey
GQLYCRTUQGSDSM-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-Methoxydiphenylmethane
CAS: 834-14-0
CID: 13264
Formula: C14H14O
MW: 198.26
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight198.26
XLogP33.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count1
Rotatable Bond Count3
Exact Mass198.104465066
Monoisotopic Mass198.104465066
Topological Polar Surface Area9.2 Ų
Heavy Atom Count15
Formal Charge0
Complexity164
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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