3-Hydroxy-2-pyrone

• Description :

  3-Hydroxy-2-pyrone (Compound 12d) is a metalloenzyme inhibitor. 3-Hydroxy-2-pyrone shows an inhibition rate of approximately 50% for matrix metalloproteinases (MMP) and the inhibition rate for non-heme iron enzyme 5-lipoxygenase (5-LOX) was over 70% at 1 mM. 3-Hydroxy-2-pyrone also has certain inhibitory activity against copper-dependent enzyme tyrosinase. 3-Hydroxy-2-pyrone can be used for the research of cancer, infection and inflammation[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Lipoxygenase; MMP; Tyrosinase

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Cancer; Infection; Inflammation/Immunology

• Purity :

  99.61

• Smiles :

  O=C1OC=CC=C1O

• Molecular Formula :

  C5H4O3

• Molecular Weight :

  112.08

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Jacobsen JA, et al. Identifying chelators for metalloprotein inhibitors using a fragment-based approach. J Med Chem. 2011 Jan 27;54 (2) :591-602.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  Store at room temperature 3 years

• Scientific Category :

  Reference compound2

• Clinical Information :

  No Development Reported

• CAS Number :

  [496-64-0]