3-Hydroxy-2-pyrone

• Description:

  3-Hydroxy-2-pyrone (Compound 12d) is a metalloenzyme inhibitor. 3-Hydroxy-2-pyrone shows an inhibition rate of approximately 50% for matrix metalloproteinases (MMP) and the inhibition rate for non-heme iron enzyme 5-lipoxygenase (5-LOX) was over 70% at 1 mM. 3-Hydroxy-2-pyrone also has certain inhibitory activity against copper-dependent enzyme tyrosinase. 3-Hydroxy-2-pyrone can be used for the research of cancer, infection and inflammation[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Lipoxygenase; MMP; Tyrosinase

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Cancer; Infection; Inflammation/Immunology

• Purity:

  99.61

• Smiles:

  O=C1OC=CC=C1O

• Molecular Formula:

  C5H4O3

• Molecular Weight:

  112.08

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Jacobsen JA, et al. Identifying chelators for metalloprotein inhibitors using a fragment-based approach. J Med Chem. 2011 Jan 27;54 (2) :591-602.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  Store at room temperature 3 years

• Scientific Category:

  Reference compound2

• Clinical Information:

  No Development Reported

• CAS Number:

  [496-64-0]