Methyl succinate

• Description:

  Methyl succinate is a mitochondrial complex II substrate. Methyl succinate can bypass the inhibition of complex I by Metformin (HY-B0627), restore mitochondrial electron transfer, and reduce AMPK phosphorylation. Methyl succinate is capable of protecting MIN6 β-cells and primary rat β-cells from biguanide-induced toxicity and apoptosis in vitro. Methyl succinate can be used in the research of diseases such as diabetes mellitus[1].

• UNSPSC:

  12352211

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  AMPK; Apoptosis

• Related Pathways:

  Apoptosis; Epigenetics; PI3K/Akt/mTOR

• Field of Research:

  Metabolic Disease

• Concentration:

  10mM

• Purity:

  99.78

• Smiles:

  O=C(CCC(OC)=O)O

• Molecular Formula:

  C5H8O4

• Molecular Weight:

  132.11

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Hinke SA, et al. Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer. Br J Pharmacol. 2007 Apr;150 (8) :1031-43

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  Store at room temperature 3 years

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  [3878-55-5]