5-Hydroxyindole (Standard)

CAT: 0804-HY-W001160R-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0804-HY-W001160R-01Size:25 mg
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Description
5-Hydroxyindole (Standard) is the analytical standard of 5-Hydroxyindole (HY-W001160) . This product is intended for research and analytical applications. 5-Hydroxyindole is an orally active hydroxylated indole and tryptophan metabolite. 5-Hydroxyindole activates α7 nicotinic acetylcholine receptors and acts on intestinal L-type calcium channels. 5-Hydroxyindole slows down the desensitization of 5-HT3 receptor-mediated ion currents in cells. 5-Hydroxyindole causes convulsions and loss of consciousness. 5-Hydroxyindole is used in the study of neuroblastoma, schizophrenia, and diseases related to intestinal motility disorders[1][2][3][4][5][6][7].
CAS Number
[1953-54-4]
UNSPSC
12352005
Target
Calcium Channel; Endogenous Metabolite; nAChR; Reference Standards
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others
Field of Research
Cancer; Endocrinology; Neurological Disease
Smiles
OC1=CC2=C(C=C1)NC=C2
Molecular Formula
C8H7NO
Molecular Weight
133.15
References & Citations
[1]Kooyman AR, et, al. 5-Hydroxyindole slows desensitization of the 5-HT3 receptor-mediated ion current in N1E-115 neuroblastoma cells. Br J Pharmacol. 1993 Feb;108 (2) :287-9.|[2]LaPorte M, et, al. 5-Hydroxyindoles by intramolecular alkynol-furan diels-alder cycloaddition. J Org Chem. 2013 Jan 4;78 (1) :167-74.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Isoform
L-type calcium channel; Microbial Metabolite

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