4-Hydroxyindole

• Description:

  4-Hydroxyindole is a type of hydroxyindole in which the 1H-indole at position 4 is substituted by a hydroxyl group. 4-Hydroxyindole serves as an important raw material or intermediate in the synthesis of pharmaceutical products and industrial polymers. 4-Hydroxyindole inhibits amyloid fibrillization and induces liver function impairment, thyroid abnormalities, and blood glucose fluctuations in mice. 4-Hydroxyindole holds potential for research in neurodegenerative diseases and metabolic disorders[1][2][3].

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H335

• Target:

  Amyloid-β; Biochemical Assay Reagents

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling; Others

• Field of Research:

  Metabolic Disease; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/4-hydroxyindole.html

• Purity:

  99.49

• Solubility:

  DMSO : 15.71 mg/mL (ultrasonic) |H2O : 1.43 mg/mL (ultrasonic)

• Smiles:

  OC1=CC=CC2=C1C=CN2

• Molecular Formula:

  C8H7NO

• Molecular Weight:

  133.15

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Nenad Manevski, et al. Glucuronidation of psilocin and 4-hydroxyindole by the human UDP-glucuronosyltransferases. Drug Metab Dispos. 2010 Mar;38 (3) :386-95.|[2]Cohen T, et al. Inhibition of amyloid fibril formation and cytotoxicity by hydroxyindole derivatives. Biochemistry. 2006 Apr 18;45 (15) :4727-35.|[3]Goyal R N, et al. Electrochemical oxidation of 4-hydroxyindole and effects of its oxidation products on blood parameters of albino mice[J]. Bioorganic Chemistry, 1999, 27 (3) : 239-252.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light, stored under nitrogen)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2380-94-1]