4-Hydroxyindole

CAT: 0804-HY-34596-01Size: 1 gDry Ice: NoHazardous: No
CAT#:0804-HY-34596-01Size:1 g
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Description
4-Hydroxyindole is a type of hydroxyindole in which the 1H-indole at position 4 is substituted by a hydroxyl group. 4-Hydroxyindole serves as an important raw material or intermediate in the synthesis of pharmaceutical products and industrial polymers. 4-Hydroxyindole inhibits amyloid fibrillization and induces liver function impairment, thyroid abnormalities, and blood glucose fluctuations in mice. 4-Hydroxyindole holds potential for research in neurodegenerative diseases and metabolic disorders[1][2][3].
CAS Number
[2380-94-1]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Amyloid-β; Biochemical Assay Reagents
Type
Reference compound
Related Pathways
Neuronal Signaling; Others
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/4-hydroxyindole.html
Purity
99.49
Solubility
DMSO : 15.71 mg/mL (ultrasonic) |H2O : 1.43 mg/mL (ultrasonic)
Smiles
OC1=CC=CC2=C1C=CN2
Molecular Formula
C8H7NO
Molecular Weight
133.15
Precautions
H315, H319, H335
References & Citations
[1]Nenad Manevski, et al. Glucuronidation of psilocin and 4-hydroxyindole by the human UDP-glucuronosyltransferases. Drug Metab Dispos. 2010 Mar;38 (3) :386-95.|[2]Cohen T, et al. Inhibition of amyloid fibril formation and cytotoxicity by hydroxyindole derivatives. Biochemistry. 2006 Apr 18;45 (15) :4727-35.|[3]Goyal R N, et al. Electrochemical oxidation of 4-hydroxyindole and effects of its oxidation products on blood parameters of albino mice[J]. Bioorganic Chemistry, 1999, 27 (3) : 239-252.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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