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JB-1

CAT: 0804-HY-P3226-03Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P3226-03Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JB-1, an IGF-1 peptide analog, is a selective and potent IGF-1R antagonist. JB-1 competes with IGF-1 by binding the IGF-1 receptor. JB-1 prevents the autophosphorylation of IGF-1R, and has no activity in IGF-II[1].
CAS Number
147819-32-7
UNSPSC
12352209
Target
IGF-1R
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Purity
99.63
Solubility
H2O : 100 mg/mL
Smiles
O=C1N2[C@@](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CSSC[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N3[C@](CCC3)([H])C(N[C@H](C(N[C@H]1CCCCN)=O)CC(C)C)=O)=O)C)=O)C)=O)CC4=CC=C(C=C4)O)=O)N)C(O)=O)=O)CO)=O)CCCCN)=O)C)=O)([H])CCC2
Molecular Formula
C55H88N14O15S2
Molecular Weight
1249.50
References & Citations
[1]Brock RS, et al. Biomolecular effects of JB1 (an IGF-I peptide analog) in a rat model of oxygen-induced retinopathy. Pediatr Res. 2011 Feb;69 (2) :135-41.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

Chemical Information

H 1356

an insulin-like growth factor 1(IGF-I) analog; inhibits autophosphorylation of IGF-I receptor

CAS Number147819-32-7
PubChem CID5491959
IUPAC Name(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-3-(7-hydroxy-3,8-dithiatricyclo[5.1.0.02,4]oct-5-en-4-yl)propanoyl]amino]propanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]propanoyl]amino]hexanoyl]amino]-3-oxopropanoyl]amino]propanoic acid
Molecular FormulaC55H88N14O15S2
Molecular Weight1249.5
XLogP-4.7
Topological Polar Surface Area506
Hydrogen Bond Donor Count14
Hydrogen Bond Acceptor Count20
Rotatable Bond Count34
Heavy Atom Count86
Formal Charge0
Complexity2580
SMILES
C[C@@H](C(=O)N[C@@H](CC12C=CC3(C(C1S2)S3)O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N4CCC[C@H]4C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N5CCC[C@H]5C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C=O)C(=O)N[C@@H](C)C(=O)O)N
InChI
InChI=1S/C55H88N14O15S2/c1-27(2)24-35(65-50(79)39-17-12-22-68(39)51(80)31(6)61-43(72)29(4)59-47(76)36(66-42(71)28(3)58)25-54-18-19-55(84)41(86-55)40(54)85-54)46(75)64-34(15-9-11-21-57)52(81)69-23-13-16-38(69)49(78)60-30(5)44(73)63-33(14-8-10-20-56)45(74)67-37(26-70)48(77)62-32(7)53(82)83/h18-19,26-41,84H,8-17,20-25,56-58H2,1-7H3,(H,59,76)(H,60,78)(H,61,72)(H,62,77)(H,63,73)(H,64,75)(H,65,79)(H,66,71)(H,67,74)(H,82,83)/t28-,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40?,41?,54?,55?/m0/s1
InChIKey
CWDBKYUARDUIEM-KTQAENQISA-N
Chemical Structure
2D Structure
2D structure of H 1356
CAS: 147819-32-7
CID: 5491959
Formula: C55H88N14O15S2
MW: 1249.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight1249.5
XLogP3-4.7
Hydrogen Bond Donor Count14
Hydrogen Bond Acceptor Count20
Rotatable Bond Count34
Exact Mass1248.59950050
Monoisotopic Mass1248.59950050
Topological Polar Surface Area506 Ų
Heavy Atom Count86
Formal Charge0
Complexity2580
Isotope Atom Count0
Defined Atom Stereocenter Count12
Undefined Atom Stereocenter Count4
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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