JB-1

• Description :

  JB-1, an IGF-1 peptide analog, is a selective and potent IGF-1R antagonist. JB-1 competes with IGF-1 by binding the IGF-1 receptor. JB-1 prevents the autophosphorylation of IGF-1R, and has no activity in IGF-II[1].

• UNSPSC :

  12352209

• Target :

  IGF-1R

• Related Pathways :

  Protein Tyrosine Kinase/RTK

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease

• Purity :

  99.63

• Solubility :

  H2O : 100 mg/mL

• Smiles :

  O=C1N2[C@@](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CSSC[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N3[C@](CCC3)([H])C(N[C@H](C(N[C@H]1CCCCN)=O)CC(C)C)=O)=O)C)=O)C)=O)CC4=CC=C(C=C4)O)=O)N)C(O)=O)=O)CO)=O)CCCCN)=O)C)=O)([H])CCC2

• Molecular Formula :

  C55H88N14O15S2

• Molecular Weight :

  1249.50

• References & Citations :

  [1]Brock RS, et al. Biomolecular effects of JB1 (an IGF-I peptide analog) in a rat model of oxygen-induced retinopathy. Pediatr Res. 2011 Feb;69 (2) :135-41.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported

• CAS Number :

  [147819-32-7]