Tachyplesin I (TFA)

• Description:

  Tachyplesin I TFA is a β-hairpin antimicrobial peptide that contains 17 amino acid residues. Tachyplesin I TFA exhibits cytotoxic properties against various human tumor cell lines acting primarily by impairing the integrity of the outer cell membrane[1].

• UNSPSC:

  12352209

• Target:

  Bacterial

• Related Pathways:

  Anti-infection

• Field of Research:

  Cancer; Infection

• Purity:

  91.83

• Smiles:

  O=C(O)C(F)(F)F.O=C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCNC(N)=N)C(N)=O)=O)NC3=O)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@@H](CCCNC(N)=N)C(N[C@H]3CCCNC(N)=N)=O)=O)=O)NC6=O)C(N[C@@H](CC7=CC=C(C=C7)O)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@H]6[C@@H](C)CC)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN)N.[x]

• Molecular Formula:

  C99H151N35O19S4.xC2HF3O2

• Molecular Weight:

  2263.74 (free base)

• References & Citations:

  [1]D V Kuzmin, et al. In Vitro Study of Antitumor Effect of Antimicrobial Peptide Tachyplesin I in Combination with Cisplatin. Bull Exp Biol Med. 2018 Jun;165 (2) :220-224.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported