Tachyplesin-3

• Description:

  Tachyplesin-3 is a broad-spectrum cationic antimicrobial peptide. Tachyplesin-3 has inhibitory activity against Gram-positive bacteria, Gram-negative bacteria, fungi and enveloped viruses. Tachyplesin-3 binds to bacterial membrane lipopolysaccharides through positive charges, disrupting membrane integrity and causing leakage of cellular contents. Tachyplesin-3 interferes with bacterial adhesion and aggregation, prevents biofilm formation, and has a synergistic effect when used in combination with Piperacillin (HY-B1923) - Tazobactam (HY-B1418) (TZP) [1].

• UNSPSC:

  12352209

• Target:

  Bacterial; Fungal

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection

• Smiles:

  O=C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)NC3=O)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@@H](CCCNC(N)=N)C(N[C@H]3CCCCN)=O)=O)=O)NC6=O)C(N[C@@H](CC7=CC=C(C=C7)O)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@H]6[C@@H](C)CC)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN)N

• Molecular Formula:

  C99H150N32O20S4

• Molecular Weight:

  2236.71

• References & Citations:

  [1]Minardi D, et al. The antimicrobial peptide tachyplesin III coated alone and in combination with intraperitoneal piperacillin-tazobactam prevents ureteral stent Pseudomonas infection in a rat subcutaneous pouch model. Peptides. 2007 Dec;28 (12) :2293-8.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported