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NLS (PKKKRKV)

CAT: 0804-HY-P1876-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P1876-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NLS (PKKKRKV) is a nuclear localization signal (NLS) derived from the simian virus 40 large tumor antigen (SV40 large T antigen), that mediates binding of the karyophilic protein to importin α. NLS (PKKKRKV) can function as a method to enhance nuclear entry in the field of gene transfer research[1][2].
CAS Number
95088-49-6
UNSPSC
12352209
Hazard Statement
H302, H315, H319
Target
DNA/RNA Synthesis
Type
Peptides
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nls-pkkkrkv.html
Purity
99.03
Solubility
10 mM in DMSO
Smiles
CC(C)[C@@H](C(O)=O)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H]1NCCC1)=O)=O)=O)=O)=O)=O
Molecular Formula
C40H78N14O8
Molecular Weight
883.14
Precautions
H302, H315, H319
References & Citations
[1]Zanta MA, et al. Gene delivery: A single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus. Proc Natl Acad Sci U S A. 1999 Jan 5;96 (1) :91-6.|[2]Cao S, et al. Enhanced effect of nuclear localization signal peptide during ultrasound‑targeted microbubble destruction‑mediated gene transfection. Mol Med Rep. 2017 Jul;16 (1) :565-572.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Citation 01
Mikrochim Acta. 2025 Aug 23;192 (9) :616.|Microchem. J.. 2025 Jun.|Mol Cancer. 2025 Jan 13;24 (1) :12.

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