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NLS (PKKKRKV)

CAT: 0804-HY-P1876-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P1876-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NLS (PKKKRKV) is a nuclear localization signal (NLS) derived from the simian virus 40 large tumor antigen (SV40 large T antigen), that mediates binding of the karyophilic protein to importin α. NLS (PKKKRKV) can function as a method to enhance nuclear entry in the field of gene transfer research[1][2].
CAS Number
95088-49-6
UNSPSC
12352209
Hazard Statement
H302, H315, H319
Target
DNA/RNA Synthesis
Type
Peptides
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nls-pkkkrkv.html
Purity
99.03
Solubility
10 mM in DMSO
Smiles
CC(C)[C@@H](C(O)=O)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H]1NCCC1)=O)=O)=O)=O)=O)=O
Molecular Formula
C40H78N14O8
Molecular Weight
883.14
Precautions
H302, H315, H319
References & Citations
[1]Zanta MA, et al. Gene delivery: A single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus. Proc Natl Acad Sci U S A. 1999 Jan 5;96 (1) :91-6.|[2]Cao S, et al. Enhanced effect of nuclear localization signal peptide during ultrasound‑targeted microbubble destruction‑mediated gene transfection. Mol Med Rep. 2017 Jul;16 (1) :565-572.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Citation 01
Mikrochim Acta. 2025 Aug 23;192 (9) :616.|Microchem. J.. 2025 Jun.|Mol Cancer. 2025 Jan 13;24 (1) :12.

Chemical Information

Nls (pkkkrkv)
CAS Number95088-49-6
PubChem CID445360
IUPAC Name(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-pyrrolidine-2-carbonyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-methylbutanoic acid
Molecular FormulaC40H78N14O8
Molecular Weight883.1
XLogP-5.1
Topological Polar Surface Area392
Hydrogen Bond Donor Count14
Hydrogen Bond Acceptor Count14
Rotatable Bond Count34
Heavy Atom Count62
Formal Charge0
Complexity1420
SMILES
CC(C)[C@@H](C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1
InChI
InChI=1S/C40H78N14O8/c1-25(2)32(39(61)62)54-38(60)30(16-6-10-22-44)52-37(59)31(18-12-24-48-40(45)46)53-36(58)29(15-5-9-21-43)51-35(57)28(14-4-8-20-42)50-34(56)27(13-3-7-19-41)49-33(55)26-17-11-23-47-26/h25-32,47H,3-24,41-44H2,1-2H3,(H,49,55)(H,50,56)(H,51,57)(H,52,59)(H,53,58)(H,54,60)(H,61,62)(H4,45,46,48)/t26-,27-,28-,29-,30-,31-,32-/m0/s1
InChIKey
HUQAPORYWLIQAO-YYGRSCHNSA-N
Chemical Structure
2D Structure
2D structure of Nls (pkkkrkv)
CAS: 95088-49-6
CID: 445360
Formula: C40H78N14O8
MW: 883.1
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight883.1
XLogP3-5.1
Hydrogen Bond Donor Count14
Hydrogen Bond Acceptor Count14
Rotatable Bond Count34
Exact Mass882.61270550
Monoisotopic Mass882.61270550
Topological Polar Surface Area392 Ų
Heavy Atom Count62
Formal Charge0
Complexity1420
Isotope Atom Count0
Defined Atom Stereocenter Count7
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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