CP-EPS8-NLS

• Description:

  CP-EPS8-NLS is a peptide with anti-AML property. CP-EPS8-NLS interferes with EPS8-associated signaling and exerts anti-AML activity in various AML cell types. CP-EPS8-NLS has potent antitumor activity in xenograft tumor models. CP-EPS8-NLS downregulates EPS8 expression and its downstream pathway[1].

• UNSPSC:

  12352209

• Target:

  Complement System

• Related Pathways:

  Immunology/Inflammation

• Field of Research:

  Cancer

• Smiles:

  O=C(C)NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N1[C@H](C(N[C@@H](CCC(N)=O)C(N[C@H](CO)C(N[C@@H](CCCCN)C(N[C@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@H](CCCCN)C(N[C@@H](CC(N)=O)C(N[C@H](CCCCN)C(N[C@@H](CCCCN)C(NCC(N[C@@H](CCCCN)C(N[C@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCC1)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

• Molecular Formula:

  C130H249N61O29

• Molecular Weight:

  3130.76

• References & Citations:

  [1]Chen, Y., et al., (2018) . A synthetic cell-penetrating peptide derived from nuclear localization signal of EPS8 exerts anticancer activity against acute myeloid leukemia. Journal of experimental & clinical cancer research : CR, 37 (1), 12.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported