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[Ala92]-p16 (84-103)

CAT: 0804-HY-P1109-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P1109-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
[Ala92]-p16 (84-103) is a peptide derived from the p16CDKN2/INK4a (p16) tumor suppressor protein. [Ala92]-p16 (84-103) binds to both cdk4 and cdk6 and inhibits cdk4-cyclin D1 kinase activity in vitro (IC50: 1.5 μM) . [Ala92]-p16 (84-103) blocks cell cycle progression through the G1 phase[1].
CAS Number
189064-08-2
UNSPSC
12352209
Target
CDK
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Purity
98.16
Solubility
H2O : 20 mg/mL (ultrasonic)
Smiles
[Asp-Ala-Ala-Arg-Glu-Gly-Phe-Leu-Ala-Thr-Leu-Val-Val-Leu-His-Arg-Ala-Gly-Ala-Arg]
Molecular Formula
C93H155N31O26
Molecular Weight
2123.42
References & Citations
[1]Fåhraeus R, et al. Characterization of the cyclin-dependent kinase inhibitory domain of the INK4 family as a model for a synthetic tumour suppressor molecule. Oncogene. 1998 Feb 5;16 (5) :587-96.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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