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NLS-StAx-h (TFA)

CAT: 0804-HY-P2272A-01Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-P2272A-01Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NLS-StAx-h TFA is a selective, cell permeable, stapled peptide Wnt signaling inhibitor with an IC50 of 1.4 μM. NLS-StAx-h TFA efficiently inhibits β-catenin-transcription factor interactions. NLS-StAx-h TFA shows anti-proliferation of cancer cells[1][2].
UNSPSC
12352209
Target
Wnt; β-catenin
Type
Peptides
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nls-stax-h-tfa.html
Purity
99.14
Solubility
DMSO : ≥ 100 mg/mL
Smiles
OC(C[C@H](NC([C@H](CC(C)C)NC([C@H]([C@@H](C)CC)N1)=O)=O)C(N[C@@](C(NC)=O)(C)CCC/C=C\CCC[C@](C)(NC)C1=O)=O)=O.[VH]N[C@H](C(N[C@H](C([V][W]N[C@H](C(N)=O)CCCCNC(N)=N)=O)CCCCNC(N)=N)=O)CCCCNC(N)=N.OC(C(F)(F)F)=O.[PKKKRKV-PEG2-Har-Har-WP-Har]
Molecular Formula
C162H276F3N55O31
Molecular Weight
3559.28
References & Citations
[1]Dietrich L, et al. Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling that Targets β-Catenin Protein-Protein Interactions. Cell Chem Biol. 2017 Aug 17;24 (8) :958-968.e5.|[2]Wang Z, et al. Direct targeting of β-catenin in the Wnt signaling pathway: Current progress and perspectives. Med Res Rev. 2021 Jul;41 (4) :2109-2129.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Scientific Category
Peptides
Clinical Information
No Development Reported

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