Nef-M1

• Description:

  Nef-M1 (Nef-Motif-1) is an antagonist peptide targeting CXCR4 and an apoptosis inducer derived from a myristoylated protein encoded by the nef gene in HIV. Nef-M1 inhibits tumor angiogenesis and epithelial-mesenchymal transition (EMT) . Nef-M1 activates the apoptosis pathway by increasing the level of caspase-3 in cancer cells. Nef-M1 simultaneously inhibits VEGF-A, p-GSK-3β and vimentin, and enhances E-cadherin, thereby inhibiting angiogenesis and EMT processes. Nef-M1 can be used in the study of colorectal cancer and breast cancer[1][2].

• UNSPSC:

  12352209

• Target:

  Apoptosis; Cadherin; Caspase; CXCR; GSK-3; VEGFR

• Related Pathways:

  Apoptosis; Cytoskeleton; GPCR/G Protein; Immunology/Inflammation; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Field of Research:

  Cancer

• Smiles:

  O=C(N[C@@H](CC(N)=O)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CS)C(N[C@@H](C)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](C)C(N[C@@H](CCC(N)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@H](O)C)N

• Molecular Formula:

  C50H76N14O17S

• Molecular Weight:

  1177.29

• References & Citations:

  [1]Katkoori VR, et al. Nef-M1, a peptide antagonist of CXCR4, inhibits tumor angiogenesis and epithelial‑to‑mesenchymal transition in colon and breast cancers. Oncotarget. 2015 Sep 29;6 (29) :27763-77.|[2]Harrington W, et al. HIV Nef-M1 Effects on Colorectal Cancer Growth in Tumor-induced Spleens and Hepatic Metastasis. Mol Cell Pharmacol. 2009 Aug 5;1 (2) :85-91.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• Isoform:

  Caspase 3; CXCR4; GSK-3β; VEGFR1/Flt-1

• CAS Number:

  [860401-80-5]