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M1-20

CAT: 0804-HY-P11028Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-P11028Size:1 Each
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Description
M1-20 is a CDK1 inhibitor. M1-20 promotes CDK1 ubiquitination by CUL4-DDB1-DCAF1 complexes and degradation through the proteasome pathway. M1-20 abolishes the formation of CDK1/CCNB1 complexes. M1-20 has significant anticancer activity of spontaneous breast cancer in FVB/N MMTV-PyVT mice model[1].
UNSPSC
12352209
Target
CDK
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCC(N)=O)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCCN)C(N[C@H](CCCCN)C(N[C@H](CCCNC(N)=N)C(N[C@H](CC(C)C)C(NCC(N1[C@H](CCC1)C(N[C@H](CC2=CC=CC=C2)C(N[C@H](CO)C(N[C@H]([C@H](C)CC)C(N[C@H](CC(O)=O)C(N[C@H](CC(C)C)C(N[C@H](CC(C)C)C(N[C@H]([C@H](C)CC)C(N[C@H](CCCCN)C(N[C@H](CO)C(N[C@H](CC(C)C)C(N[C@H](CO)C(N[C@H](CC(O)=O)C(N[C@H](CC(N)=O)C(N[C@H](CCSC)C(N[C@H]([C@@H](O)C)C(N[C@H](CC(O)=O)C(N[C@H](CC(C)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN
Molecular Formula
C153H269N53O43S
Molecular Weight
3571.17
References & Citations
[1]Bu H, et al. The antitumor peptide M1-20 induced the degradation of CDK1 through CUL4-DDB1-DCAF1-involved ubiquitination. Cancer Gene Ther. 2025 Jan;32 (1) :61-70.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
CDK1

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