Nef-M1

• CAS Number :

  860401-80-5

• Target :

  CXCR|||Cadherin|||GSK-3|||VEGFR|||Caspase|||Apoptosis

• Related Pathways :

  Immunology/Inflammation|||GPCR/G Protein|||Autophagy|||Angiogenesis|||Stem Cells|||Apoptosis|||PI3K/Akt/mTOR signaling|||Proteases/Proteasome|||Tyrosine Kinase/Adaptors|||Cytoskeletal Signaling

• Bioactivity :

  Nef-M1 (Nef-Motif-1) is an antagonist peptide targeting CXCR4 and an apoptosis (apoptosis) inducer derived from the myristoylated protein encoded by the HIV nef gene. Nef-M1 inhibits tumor angiogenesis and epithelial-mesenchymal transition (EMT) by activating the apoptotic pathway through increased levels of caspase-3 in cancer cells. Additionally, it suppresses VEGF-A, p-GSK-3?, and vimentin while enhancing E-cadherin, thereby hindering angiogenesis and EMT processes. Nef-M1 is applicable in colorectal cancer and breast cancer research.

• Smiles :

  C([C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCC(N)=O)C(O)=O)=O)C)=O)CCC(O)=O)=O)CC(C)C)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H]([C@@H](C)O)N)=O)CC(N)=O)=O)C)=O)C)=O)CS)=O)C)=O)C=1C=2C(NC1)=CC=CC2

• Molecular Formula :

  C50H76N14O17S

• Molecular Weight :

  1177.29

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C