Nef ligand-2

• Description :

  Nef ligand-2 is a binder of Nef. Nef ligand-2 is Ligands for E3 Ligase. Nef ligand-2 is the Nef Binder portion of FC-14369 (HY-171860) [1].

• UNSPSC :

  12352005

• Target :

  HIV; Ligands for E3 Ligase

• Related Pathways :

  Anti-infection; PROTAC

• Field of Research :

  Infection

• Smiles :

  O=C(COC1=CC=C(CCC2=C(O)N(C3=NC4=C(N3)C=C(Cl)C=C4)N=C2C5=CC=C(C(F)(F)F)C=C5)C=C1)O

• Molecular Formula :

  C27H20ClF3N4O4

• Molecular Weight :

  556.92

• References & Citations :

  [1]Emert-Sedlak LA, et al. PROTAC-mediated degradation of HIV-1 Nef efficiently restores cell-surface CD4 and MHC-I expression and blocks HIV-1 replication. Cell Chem Biol. 2024 Apr 18;31 (4) :658-668.e14.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [3066896-28-1]