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Amilo-5MER (TFA)

CAT: 0804-HY-P10935A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P10935A-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Amilo-5MER (5-MP) TFA is an orally active and selective Serum Amyloid A (SAA) inhibitor. Amilo-5MER TFA specifically inhibits the release of pro-inflammatory cytokines IL-6 and IL-1β from SAA-activated cells. Amilo-5MER TFA reduces chronic inflammation and relieves symptoms of diseases such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and multiple sclerosis (MS) . Amilo-5MER TFA is promising for research of autoimmune diseases and chronic inflammatory diseases[1].
Product Name Alternative
5-MP (TFA)
UNSPSC
12352209
Target
Amyloid-β; Interleukin Related
Related Pathways
Immunology/Inflammation; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Inflammation/Immunology
Purity
99.63
Solubility
0.1 M Acetic acid : 0.5 mg/mL (ultrasonic) |DMSO : 25 mg/mL (ultrasonic)
Smiles
CC(C)[C@@H](C(N)=O)NC([C@H](CC(O)=O)NC([C@H](C)NC([C@H]([C@H](O)C)NC([C@@H](NC(C)=O)CCSC)=O)=O)=O)=O.O=C(C(F)(F)F)O.[x]
Molecular Formula
C23H40N6O9S.xC2HF3O2
Molecular Weight
576.66 (free base)
References & Citations
[1]Hemed-Shaked M, et al. MTADV 5-MER peptide suppresses chronic inflammations as well as autoimmune pathologies and unveils a new potential target-Serum Amyloid A. J Autoimmun. 2021 Nov;124:102713.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
Phase 1

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