BMP-4 (acetate)

• Description:

  BMP-4 acetate is a penetrating heparin-binding peptide with anti-inflammatory and anti-chondrogenic functions. BMP-4 acetate regulates the iNOS-IFN-IL6 signaling pathway to inhibit the expression of inflammatory proteins such as iNOS, COX2, IFN, and IL6, effectively suppressing inflammation and alleviating various arthritis symptoms in murine chondrocytes and macrophages[1].

• UNSPSC:

  12352209

• Target:

  COX; IFNAR; Interleukin Related

• Related Pathways:

  Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Purity:

  99.30

• Solubility:

  DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CC(N)=O)C(N1[C@@H](CCC1)C(N[C@@H](CC(N)=O)C(N[C@@H](CS)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC2=CNC=N2)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCNC(N)=N)N.CC(O)=O.[x]

• Molecular Formula:

  C52H93N25O13S.xC2HFO2

• Molecular Weight:

  1308.52 (free base)

• References & Citations:

  [1]Pathade V, et al. Emerging insights of peptide-based nanotherapeutics for effective management of rheumatoid arthritis. Life Sci. 2023 Jan 1;312:121257.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• Isoform:

  COX-2; IL-6