4-Hydroxyphenyl acetate

• UNSPSC Description:

  4-Hydroxyphenyl acetate (4-HPA) is a natural antioxidant and protects cells from oxidative stress-induced necrosis. 4-Hydroxyphenyl acetate blocks the increase of cellular ROS induced by oxidative stress, and up-regulates NQO1 and HO-1 genes by stabilizing and inducing the nuclear translocation of NRF2 transcription factor[1].

• Target Antigen:

  Endogenous Metabolite

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/4-hydroxyphenyl-acetate.html

• Purity:

  99.98

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(C)OC(C=C1)=CC=C1O

• Molecular Weight:

  152.149

• References & Citations:

  [1]Hanus J, et, al. 4-Acetoxyphenol Prevents RPE Oxidative Stress-Induced Necrosis by Functioning as an NRF2 Stabilizer. Invest Ophthalmol Vis Sci. 2015 Aug;56(9):5048-59.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  3233-32-7