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Ac-MRGDH-NH2

CAT: 0804-HY-P10667Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P10667Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ac-MRGDH-NH2 is a pentapeptide containing the RGD sequence. Ac-MRGDH-NH2 can be used to synthesize the diastereoisomeric prodrugs Λ- and Δ-[Ru (Ph2phen) 2 (κS, κN- (Ac-MRGDH-NH2) ) ]Cl2. In these prodrugs, Ac-MRGDH-NH2 serves as a photolabile protecting group for the cytotoxic bis-aqua ruthenium warhead [Ru (Ph2phen) 2 (OH2) 2]2+, and Ac-MRGDH-NH2 possesses integrin targeting ability and photosubstitution properties. Therefore, Ac-MRGDH-NH2 can be utilized in research on tumor-targeted photodynamic activation chemotherapy (PACT) [1].
UNSPSC
12352209
Target
Integrin
Related Pathways
Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(N[C@@H](CCSC)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CC(O)=O)C(N[C@@H](CC1=CNC=N1)C(N)=O)=O)=O)=O)=O)C
Molecular Formula
C25H41N11O8S
Molecular Weight
655.73
References & Citations
[1]Zhang L, et al. Cyclic ruthenium-peptide conjugates as integrin-targeting phototherapeutic prodrugs for the treatment of brain tumors[J]. Journal of the American Chemical Society, 2023, 145 (27) : 14963-14980.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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