SsK36 (TFA)

CAT: 0804-HY-P10463A-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-P10463A-01Size:5 mg
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Description
SsK36 TFA is a supersubstrate peptide of the histone methyltransferase (SET) domain protein 2 (SETD2), and ssK36 TFA is designed for the SETD2 protein, a specific PKMT. ssK36 TFA is responsible in human cells for adding methyl groups to the 36th lysine residue of histone H3 (H3K36) to form H3K36me3. ssK36 TFA can be methylated by SETD2 at a rate more than 100 times faster than the natural substrate H3K36. ssK36 TFA can be used to study the catalytic mechanism of PKMTs, especially substrate specificity and catalytic efficiency[1].
UNSPSC
12352209
Target
Histone Methyltransferase
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.34
Solubility
H2O : 1 mg/mL (ultrasonic)
Smiles
O=C(N1[C@@H](CCC1)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC2=CC=CC=C2)C(NCC(NCC(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N3[C@@H](CCC3)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC4=CC=C(C=C4)O)C(N[C@@H](CCCNC(N)=N)C(N5[C@@H](CCC5)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C)N.O=C(O)C(F)(F)F.[x]
Molecular Formula
C79H127N29O18.xC2HF3O2
Molecular Weight
1771.04 (free base)
References & Citations
[1]Schnee P, et al. Mechanistic basis of the increased methylation activity of the SETD2 protein lysine methyltransferase towards a designed super-substrate peptide[J]. Communications Chemistry, 2022, 5 (1) : 139.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

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