2-ACC

• Description :

  2-ACC (2-α-Carboxy cholestanol) is a cholestanol, is a mutant Sonic Hedgehog protein D46A activator with an EC50 of ～5 μM.

• Product Name Alternative :

  2-α-Carboxy cholestanol

• UNSPSC :

  12352100

• Target :

  Hedgehog

• Related Pathways :

  Stem Cell/Wnt

• Field of Research :

  Metabolic Disease

• Smiles :

  C[C@@]12[C@]3([H])[C@](CC[C@@]1([H])C[C@H]([C@@H](C2)C(O)=O)O)([H])[C@@]4([H])[C@](CC3)([C@@](CC4)([H])[C@H](C)CCCC(C)C)C

• Molecular Formula :

  C28H48O3

• Molecular Weight :

  432.68

• References & Citations :

  [1]Ciulla DA, et al. A cell-based bioluminescence reporter assay of human Sonic Hedgehog protein autoprocessing to identify inhibitors and activators. J Biol Chem. 2022 Dec;298 (12) :102705.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [3091880-01-9]