2-ACC

• Description:

  2-ACC (2-α-Carboxy cholestanol) is a cholestanol, is a mutant Sonic Hedgehog protein D46A activator with an EC50 of ～5 μM.

• Product Name Alternative:

  2-α-Carboxy cholestanol

• UNSPSC:

  12352100

• Target:

  Hedgehog

• Related Pathways:

  Stem Cell/Wnt

• Field of Research:

  Metabolic Disease

• Smiles:

  C[C@@]12[C@]3 ([H]) [C@] (CC[C@@]1 ([H]) C[C@H] ([C@@H] (C2) C (O) =O) O) ([H]) [C@@]4 ([H]) [C@] (CC3) ([C@@] (CC4) ([H]) [C@H] (C) CCCC (C) C) C

• Molecular Formula:

  C28H48O3

• Molecular Weight:

  432.68

• References & Citations:

  [1]Ciulla DA, et al. A cell-based bioluminescence reporter assay of human Sonic Hedgehog protein autoprocessing to identify inhibitors and activators. J Biol Chem. 2022 Dec;298 (12) :102705.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  3091880-01-9