ACC-IN-1

• Description:

  ACC-IN-1 (Compound B1) is an allosteric inhibitor of acetyl-CoA carboxylase (ACC) . ACC-IN-1 targets ACC to regulate lipid metabolism, which can improve liver steatosis, inflammation related to non-alcoholic steatohepatitis (NASH) [1].

• UNSPSC:

  12352005

• Target:

  Acetyl-CoA Carboxylase

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Inflammation/Immunology

• Smiles:

  O=C (O) [C@@]1 (C[C@@H] (C1) N (C2=O) C (N (C3=C2C (C) =C (S3) C4=NC=CO4) C[C@H] (OC5CCOCC5) C6=CC=CC=C6OC) =O) C

• Molecular Formula:

  C30H33N3O8S

• Molecular Weight:

  595.66

• References & Citations:

  [1]Wang Y, et al. Identification of Novel Cyclobutane-Based Derivatives as Potent Acetyl-CoA Carboxylase Allosteric Inhibitors for Nonalcoholic Steatohepatitis Drug Discovery. J Med Chem. 2025 Apr 24;68 (8) :8578-8599.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2270839-89-7