Chaetoglobosin E

• Description :

  Chaetoglobosin E is a Ferroptosis inducer that exhibits significant cytotoxicity against human tumor cell lines MDA-MB231 and A549, with IC50 values of 9.14 and 7.47 μM, respectively. By downregulating the expression of GPX4 in A549 cells, Chaetoglobosin E markedly increases intracellular levels of Fe2+ and the lipid peroxidation product malondialdehyde (MDA), leading to mitochondrial shrinkage, reduction or disappearance of cristae, and subsequent induction of ferroptosis. Chaetoglobosin E can be used for research in the field of cancer[1].

• CAS Number :

  [55945-74-9]

• UNSPSC :

  12352005

• Target :

  Ferroptosis

• Related Pathways :

  Apoptosis

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Smiles :

  CC1=C(C)[C@]([C@@H](N2)CC3=CNC4=C3C=CC=C4)([H])[C@@]([C@](/C=C/C[C@H](C)/C=C5\C)([H])[C@@H]1O)(C(CC[C@H](O)C5=O)=O)C2=O

• Molecular Formula :

  C32H38N2O5

• Molecular Weight :

  530.65

• References & Citations :

  [1]Wang YY, et al. Unusual chaetoglobosins and a new type of ferroptosis inducer from an endophytic fungus Chaetomium sp. UJN-EF006. Bioorg Chem. 2025 May;158:108342.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported