Chaetoglobosin E

CAT: 0804-HY-N15398Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-N15398Size:1 Each
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Description
Chaetoglobosin E is a Ferroptosis inducer that exhibits significant cytotoxicity against human tumor cell lines MDA-MB231 and A549, with IC50 values of 9.14 and 7.47 μM, respectively. By downregulating the expression of GPX4 in A549 cells, Chaetoglobosin E markedly increases intracellular levels of Fe2+ and the lipid peroxidation product malondialdehyde (MDA), leading to mitochondrial shrinkage, reduction or disappearance of cristae, and subsequent induction of ferroptosis. Chaetoglobosin E can be used for research in the field of cancer[1].
CAS Number
[55945-74-9]
UNSPSC
12352005
Target
Ferroptosis
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CC1=C(C)[C@]([C@@H](N2)CC3=CNC4=C3C=CC=C4)([H])[C@@]([C@](/C=C/C[C@H](C)/C=C5\C)([H])[C@@H]1O)(C(CC[C@H](O)C5=O)=O)C2=O
Molecular Formula
C32H38N2O5
Molecular Weight
530.65
References & Citations
[1]Wang YY, et al. Unusual chaetoglobosins and a new type of ferroptosis inducer from an endophytic fungus Chaetomium sp. UJN-EF006. Bioorg Chem. 2025 May;158:108342.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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