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Chaetoglobosin A

CAT: 0804-HY-N6744Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N6744Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Chaetoglobosin A, the active principle within the extract of Penicillium aquamarinium, is a member of the cytochalasan family. Chaetoglobosin A preferentially induces apoptosis. Chaetoglobosin A targets filamentous actin in CLL cells and thereby induces cell-cycle arrest and inhibits membrane ruffling and cell migration[1].
CAS Number
50335-03-0
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Apoptosis
Type
Natural Products
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/chaetoglobosin-a.html
Purity
99.07
Solubility
10 mM in DMSO|DMSO : ≥ 10mg/mL
Smiles
O=C(/C=C/C1=O)[C@H](O)/C(C)=C/[C@@H](C)C/C=C/[C@]2([H])[C@]31C(N[C@@H](CC4=CNC5=C4C=CC=C5)[C@]3([H])[C@H](C)[C@]6(C)[C@@]2([H])O6)=O
Molecular Formula
C32H36N2O5
Molecular Weight
528.64
Precautions
H315, H319, H335
References & Citations
[1]Knudsen PB, et al. Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton. Leukemia. 2014 Jun;28 (6) :1289-98.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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