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Chaetoglobosin E

CAT: 0931-TN10448-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-TN10448-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
55945-74-9
Target
Ferroptosis
Related Pathways
Apoptosis
Bioactivity
Chaetoglobosin E is a ferroptosis inducer exhibiting significant cytotoxicity against the human tumor cell lines MDA-MB231 and A549, with IC50 values of 9.14 μM and 7.47 μM, respectively. It induces ferroptosis by downregulating GPX4 expression in A549 cells, leading to increased intracellular levels of Fe2+ (iron ions) and the lipid peroxidation product malondialdehyde (MDA), resulting in mitochondrial shrinkage and reduced or absent cristae. Chaetoglobosin E is applicable in cancer research.
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O=C1[C@]23[C@]([C@H](CC=4C=5C(NC4)=CC=CC5)N1)(C(C)=C(C)[C@@H](O)[C@@]2(/C=C/C[C@H](C)/C=C(\C)/C(=O)[C@@H](O)CCC3=O)[H])[H]
Molecular Formula
C32H38N2O5
Molecular Weight
530.654
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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