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Argyrin B

CAT: 0804-HY-N13917Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-N13917Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Argyrin B, a natural product cyclic peptide, is a reversible, non-competitive immunoproteasome inhibitor. Argyrin B shows selective inhibition of the β5i and β1i sites of the immunoproteasome over the β5c and β1c sites of the constitutive proteasome with nearly 20-fold selective inhibition of β1i over the homologous β1c. Argyrin B has antibacterial effects[1].
CAS Number
[174423-36-0]
UNSPSC
12352005
Target
Bacterial; Proteasome
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Smiles
COC1=C2C(C[C@@H]3NC([C@@H](NC(C4=CSC([C@H](NC(CN(C(C(NC([C@H](NC(CNC3=O)=O)CC)=O)=C)=O)C)=O)C)=N4)=O)CC5=CNC6=CC=CC=C56)=O)=CNC2=CC=C1
Molecular Formula
C41H46N10O8S
Molecular Weight
838.93
References & Citations
[1]Allardyce DJ, et al. Argyrin B, a non-competitive inhibitor of the human immunoproteasome exhibiting preference for β1i. Chem Biol Drug Des. 2019 Aug;94 (2) :1556-1567.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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