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Argyrin B

CAT: 0931-TN9039-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-TN9039-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
174423-36-0
Target
Proteasome|||Antibacterial
Related Pathways
Proteases/Proteasome|||Microbiology/Virology|||Ubiquitination
Bioactivity
Argyrin B is a naturally occurring cyclic peptide that acts as a reversible non-competitive inhibitor of the immunoproteasome. It exhibits higher inhibitory selectivity for the ?5i and ?1i sites of the immunoproteasome compared to the ?5c and ?1c sites of the constitutive proteasome, being nearly 20 times more selective for ?1i than for its homolog ?1c. Additionally, Argyrin B possesses antibacterial properties.
Smiles
C(C=1C=2C(NC1)=CC=CC2OC)[C@@H]3NC(=O)[C@H](CC=4C=5C(NC4)=CC=CC5)NC(=O)C=6N=C(SC6)[C@@H](C)NC(=O)CN(C)C(=O)C(=C)NC(=O)[C@@H](CC)NC(=O)CNC3=O
Molecular Formula
C41H46N10O8S
Molecular Weight
838.931
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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