Epi lovastatin-d3

• Description:

  Epi Lovastatin-d3 is the deuterium labeled Lovastatin. Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.

• UNSPSC:

  12352005

• Target:

  Autophagy; Ferroptosis; HMG-CoA Reductase (HMGCR) ; Isotope-Labeled Compounds

• Related Pathways:

  Apoptosis; Autophagy; Metabolic Enzyme/Protease; Others

• Field of Research:

  Cardiovascular Disease; Cancer

• Solubility:

  10 mM in DMSO

• Smiles:

  O (C ([C@@H] (CC) C ([2H]) ([2H]) [2H]) =O) [C@@H]1[C@]2 (C (C=C[C@H] (C) [C@@H]2CC[C@@H]3C[C@@H] (O) CC (=O) O3) =C[C@H] (C) C1) [H]

• Molecular Formula:

  C24H33D3O5

• Molecular Weight:

  407.56

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Alberts AW, et al. Discovery, biochemistry and biology of lovastatin. Am J Cardiol. 1988 Nov 11;62 (15) :10J-15J.|[3]Kah J, et al. Selective induction of apoptosis by HMG-CoA reductase inhibitors in hepatoma cells and dependence on p53 expression. Oncol Rep. 2012 Sep;28 (3) :1077-83.|[4]Frishman WH, et al. Lovastatin: an HMG-CoA reductase inhibitor for lowering cholesterol. Med Clin North Am. 1989 Mar;73 (2) :437-48.|[5]Tobert JA, et al. Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors. Nat Rev Drug Discov. 2003 Jul;2 (7) :517-26.|[6]Ifergan I, et al. Statins reduce human blood-brain barrier permeability and restrict leukocyte migration: relevance to multiple sclerosis. Ann Neurol. 2006 Jul;60 (1) :45-55.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  1330264-51-1