Lovastatin-d3

CAT: 0804-HY-N0504S2Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N0504S2Size:1 mg
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Description
Lovastatin-d3 is deuterium labeled Lovastatin. Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.
CAS Number
[1002345-93-8]
Product Name Alternative
Mevinolin-d3
UNSPSC
12352005
Target
Autophagy; Ferroptosis; HMG-CoA Reductase (HMGCR) ; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Autophagy; Metabolic Enzyme/Protease; Others
Applications
Cancer-programmed cell death
Field of Research
Cardiovascular Disease; Cancer
Solubility
10 mM in DMSO
Smiles
CC[C@H](C([2H])([2H])[2H])C(O[C@@H]1[C@@]2([H])C(C=C[C@@H]([C@@H]2CC[C@@H]3C[C@H](CC(O3)=O)O)C)=C[C@@H](C1)C)=O
Molecular Formula
C24H33D3O5
Molecular Weight
407.56
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Alberts AW, et al. Discovery, biochemistry and biology of lovastatin. Am J Cardiol. 1988 Nov 11;62 (15) :10J-15J.|[3]Frishman WH, et al. Lovastatin: an HMG-CoA reductase inhibitor for lowering cholesterol. Med Clin North Am. 1989 Mar;73 (2) :437-48.|[4]Ifergan I, et al. Statins reduce human blood-brain barrier permeability and restrict leukocyte migration: relevance to multiple sclerosis. Ann Neurol. 2006 Jul;60 (1) :45-55.|[5]Kah J, et al. Selective induction of apoptosis by HMG-CoA reductase inhibitors in hepatoma cells and dependence on p53 expression. Oncol Rep. 2012 Sep;28 (3) :1077-83.|[6]Tobert JA, et al. Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors. Nat Rev Drug Discov. 2003 Jul;2 (7) :517-26.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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