Lovastatin

• Description:

  Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.

• Product Name Alternative:

  Mevinolin

• UNSPSC:

  12352005

• Hazard Statement:

  H351, H361

• Target:

  Autophagy; Ferroptosis; HMG-CoA Reductase (HMGCR)

• Type:

  Natural Products

• Related Pathways:

  Apoptosis; Autophagy; Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cardiovascular Disease; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Lovastatin.html

• Concentration:

  10mM

• Purity:

  99.89

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  O=C([C@@H](C)CC)O[C@@H]1[C@@]([C@H]2CC[C@@H](OC3=O)C[C@H](C3)O)([H])C(C=C[C@@H]2C)=C[C@H](C)C1

• Molecular Formula:

  C24H36O5

• Molecular Weight:

  404.54

• Precautions:

  H351, H361

• References & Citations:

  [1]Alberts AW, et al. Discovery, biochemistry and biology of lovastatin. Am J Cardiol. 1988 Nov 11;62 (15) :10J-15J.|[2]Kah J, et al. Selective induction of apoptosis by HMG-CoA reductase inhibitors in hepatoma cells and dependence on p53 expression. Oncol Rep. 2012 Sep;28 (3) :1077-83.|[3]Frishman WH, et al. Lovastatin: an HMG-CoA reductase inhibitor for lowering cholesterol. Med Clin North Am. 1989 Mar;73 (2) :437-48.|[4]Tobert JA, et al. Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors. Nat Rev Drug Discov. 2003 Jul;2 (7) :517-26.|[5]Ifergan I, et al. Statins reduce human blood-brain barrier permeability and restrict leukocyte migration: relevance to multiple sclerosis. Ann Neurol. 2006 Jul;60 (1) :45-55.|[6]Chu W, et al. Lovastatin exerts protective effects on endothelial cells via upregulation of PTK2B. Exp Ther Med. 2016 Sep;12 (3) :1741-1749. |[7]Régrigny O, et al. Effect of lovastatin on cerebral circulation in spontaneously hypertensive rats. Hypertension. 2000 May;35 (5) :1105-10.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  Launched

• CAS Number:

  [75330-75-5]