Cy3-NO2-Tre

• Description:

  Cy3-NO2-Tre is a nitroreductase-responsive cyanine-based fluorescent probe that specifically labels Mycobacterium tuberculosis (Mtb) . Cy3-NO2-tre generated fluorescence after activation by a specific nitroreductase, Rv3368c, which is conserved in the Mycobacteriaceae. Cy3-NO2-tre effectively imaged mycobacteria within infected host cells, tracked the infection process, and visualized Mycobacterium smegmatis being endocytosed by macrophages (Ex/Em= 540-550/575-625 nm) [1].

• UNSPSC:

  12171500

• Target:

  Fluorescent Dye

• Related Pathways:

  Others

• Field of Research:

  Infection

• Smiles:

  CC1(C)C2=CC=CC=C2[N+](CC3=CC=C(C=C3)[N+]([O-])=O)=C1/C=C/C=C4N(C5=CC=CC=C5C/4(C)C)CCCCCC(NC[C@H]6O[C@@H]([C@@H]([C@H]([C@@H]6O)O)O)O[C@H]7O[C@@H]([C@H]([C@@H]([C@H]7O)O)O)CO)=O.[Br-]

• Molecular Formula:

  C48H61BrN4O13

• Molecular Weight:

  981.92

• References & Citations:

  [1]Hong X, et al. From Bench to Clinic: A Nitroreductase Rv3368c-Responsive Cyanine-Based Probe for the Specific Detection of Live Mycobacterium tuberculosis. Anal Chem. 2024 Jan 30;96 (4) :1576-1586.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Dye Reagents

• Clinical Information:

  No Development Reported

• CAS Number:

  [3012597-48-4]