Norzine (dimalate)

CAT: 0804-HY-A0188-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-A0188-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Norzine dimalate (Thiethylperazine dimalate), a Phenothiazine (HY-Y0055) derivate, is an orally active and potent dopamine D2-receptor and histamine H1-receptor antagonist. Norzine dimalate is also a selective ABCC1activator that reduces amyloid-β load in mice. Norzine dimalate has anti-emetic, antipsychotic and antimicrobial effects[1][2][3].
CAS Number
[52239-63-1]
Product Name Alternative
Thiethylperazine (dimalate)
UNSPSC
12352005
Hazard Statement
H302-H410
Target
Amyloid-β; Bacterial; Dopamine Receptor; Drug Derivative; Histamine Receptor
Related Pathways
Anti-infection; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling; Others
Applications
Neuroscience-Neurodegeneration
Field of Research
Infection; Neurological Disease
Smiles
O=C(O)C(O)CC(O)=O.CN1CCN(CCCN2C3=C(C=CC=C3)SC4=CC=C(SCC)C=C24)CC1.O=C(O)C(O)CC(O)=O
Molecular Formula
C30H41N3O10S2
Molecular Weight
667.79
Precautions
P264-P270-P273-P330-P391-P501
References & Citations
[1]Czeizel AE, et al. Case-control study of teratogenic potential of thiethylperazine, an anti-emetic drug. BJOG. 2003 May;110 (5) :497-9. |[2]Krohn M, et al. Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice. J Clin Invest. 2011 Oct;121 (10) :3924-31. |[3]Rahbar M, et al. Enhancement of vancomycin activity by phenothiazines against vancomycin-resistant Enterococcus faecium in vitro. Basic Clin Pharmacol Toxicol. 2010 Aug;107 (2) :676-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
D2 Receptor; H1 Receptor

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