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UK-224671

CAT: 0804-HY-19405Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-19405Size:1 Each
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Description
UK-224671 is a potent and selective NK2 receptor antagonist. UK-224671 is affected by P-gp efflux and poor intrinsic membrane permeability, resulting in low oral bioavailability[1].
CAS Number
178309-91-6
UNSPSC
12352005
Target
Neurokinin Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Others
Smiles
O=S(N1CCN(C2CN(CC[C@@](CC3)(C4=CC=C(Cl)C(Cl)=C4)CN(CC5CC5)C3=O)C2)CC1)(C)=O
Molecular Formula
C25H36Cl2N4O3S
Molecular Weight
543.55
References & Citations
[1]Beaumont K, et al. The role of P-glycoprotein in determining the oral absorption and clearance of the NK2 antagonist, UK-224,671. Eur J Pharm Sci. 2000 Nov;12 (1) :41-50.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
NK2R

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