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PF-719

CAT: 0013-GTR19178130Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19178130Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PF-719 (PF719) is a potent, selective Pyk2 inhibitor with IC50 of 17 nM, displays 25-fold selectvity over FAK (IC50=469 nM) ; does not have significant inhibitory effects on recombinant MLCK2, p38, Akt1, or ROCK1, and very little inhibtion at Src family kinases (IC50>5 uM) ; selectively inhibits tyrosine phosphorylation of Pyk2 at 1 uM, but blocks both Pyk2 and FAK phosphorylation at 2.5 uM in A20 cells; reduces chemoattractant-induced migration of B-2 and MZ B cells.
CAS Number
1404454-02-9
Purity
>98%
Smiles
O=C (NC1CC1) C2=CC=C (NC3=NC=C (C (F) (F) F) C (N[C@H]4[C@H] (N (C) C) CCC4) =N3) C=C2
Molecular Formula
C22H29Cl2F3N6O
Molecular Weight
521.41
Notes
For research use only.

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