SB-201993

• Description :

  SB-201993 is a selective leukotriene B₄ (LTB4) receptor antagonist with a Ki=7.6 nM for LTB4 receptors on human inflammatory cells. SB-201993 inhibits calcium mobilization in inflammatory cells and 5-lipoxygenase activity, exerting anti-inflammatory effects. SB-201993 is promising for research of inflammatory diseases (e.g., dermatitis, arthritis) [1].

• UNSPSC :

  12352005

• Target :

  Leukotriene Receptor

• Related Pathways :

  GPCR/G Protein

• Field of Research :

  Inflammation/Immunology

• Smiles :

  O=C(O)C1=CC=CC(CSCC2=NC(/C=C/C(O)=O)=C(OCCCCCCCCC3=CC=C(OC)C=C3)C=C2)=C1

• Molecular Formula :

  C32H37NO6S

• Molecular Weight :

  563.70

• References & Citations :

  [1]Sarau HM, et al. In vitro and in vivo pharmacological characterization of SB 201993, an eicosanoid-like LTB4 receptor antagonist with anti-inflammatory activity. Prostaglandins Leukot Essent Fatty Acids. 1999 Jul;61 (1) :55-64.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• Isoform :

  LTB4

• CAS Number :

  [150399-22-7]