MKC-963

• Description:

  MKC-963 is an orally active and potent inhibitor targeting platelet aggregation-related pathways. MKC-963 exerts antithrombotic activity by inhibiting platelet aggregation, and can also induce autoinduction, i.e., upregulating the mRNA expression and activity of CYP3A4 enzyme to accelerate its own metabolism in vivo. MKC-963 is promising for research of platelet aggregation-related diseases (e.g., thrombosis) [1].

• UNSPSC:

  12352005

• Target:

  Platelet-activating Factor Receptor (PAFR)

• Related Pathways:

  GPCR/G Protein

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Smiles:

  C[C@@H] (NC1=NN=C (C2=CC=CC=C2) C3=C1C=CC=C3) C4CCCCC4

• Molecular Formula:

  C22H25N3

• Molecular Weight:

  331.45

• References & Citations:

  [1]Shimizu T, et al. Autoinduction of MKC-963 [ (R) -1- (1-cyclohexylethylamino) -4-phenylphthalazine] metabolism in healthy volunteers and its retrospective evaluation using primary human hepatocytes and cDNA-expressed enzymes[J]. Drug metabolism and disposition, 2006, 34 (6) : 950-954.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  149549-14-4