NSC 57148

CAT: 0804-HY-180498Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-180498Size:1 Each
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Description
NSC 57148 is a selective Grb7 SH2 domain antagonist with an IC50 value of 1.1 μM. NSC 57148 reduces cancer cell proliferation and migration. NSC 57148 is promising for research of Grb7-overexpressing malignancies such as breast and pancreatic cancers[1].
CAS Number
[4315-44-0]
UNSPSC
12352005
Target
EGFR
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(C1=CC=C(C(NC2=CC=C(C3=NC(CN3)C)C=C2)=O)C=C1)NC4=CC=C(C5=NC(CN5)C)C=C4.Cl.Cl
Molecular Formula
C28H30Cl2N6O2
Molecular Weight
553.48
References & Citations
[1]Ambaye ND, et al. The discovery of phenylbenzamide derivatives as Grb7-based antitumor agents. ChemMedChem. 2013 Feb;8 (2) :280-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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