PDK1-IN-5

CAT: 0804-HY-179501Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-179501Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PDK1-IN-5 is a selective PDK1 inhibitor. PDK1-IN-5 activaties PDH by diminishing phosphorylation level via PDK1 inhibition. PDK1-IN-5 effectively reverses the Warburg effect and shifts cellular energy metabolism from glycolysis toward oxidative phosphorylation by increased acetyl-CoA, reduced lactate, elevated mitochondrial ROS, and subsequent induction of apoptosis. PDK1-IN-5 robustly inhibits tumor growth in vivo without inducing systemic toxicity. PDK1-IN-5 can be used for lung adenocarcinoma, human non-small cell lung adenocarcinoma and gastric colorectal[1].
UNSPSC
12352005
Target
Apoptosis; Oxidative Phosphorylation; PDK-1; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(NC1=CC=C(OCC2=CC=C(OC(F)(F)F)C=C2)C=C1)C(Cl)Cl
Molecular Formula
C16H12Cl2F3NO3
Molecular Weight
394.17
References & Citations
[1]Tang M, et al. Reversing the Warburg effect: Discovery of potent pyruvate dehydrogenase kinase inhibitors for inhibiting tumor growth. Bioorg Chem. 2025 Dec;167:109224.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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