PDK1-IN-RS2

• Product Name Alternative:

  Xanthothricin; Toxoflavine; PKF-118-310

• UNSPSC Description:

  PDK1-IN-RS2 is a mimic of peptide docking motif (PIFtide) and is a substrate-selective PDK1 inhibitor with a Kd of 9 μM. PDK1-IN-RS2 suppresses the activation of the downstream kinases S6K1 by PDK1[1].

• Target Antigen:

  PDK-1

• Type:

  Reference compound

• Related Pathways:

  PI3K/Akt/mTOR

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/pdk1-in-rs2.html

• Purity:

  98.50

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  O=S(C1=CC2=CC=CC=C2S1)(NC3=NC4=CC=C(C=C4S3)Cl)=O

• Molecular Weight:

  380.89

• References & Citations:

  [1]Rettenmaier TJ, et al. A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1. Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18590-5.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  1643958-89-7