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TTK-IN-5

CAT: 0804-HY-179430Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179430Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TTK-IN-5 is an orally active covalent threonine tyrosine kinase (TTK) inhibitor with selectivity (IC50 = 8.918 nM) . TTK-IN-5 exhibits anti-proliferative potencies against MDA-MB-231, A2780, HCT116, HCC1569 and MKN1 cell lines (IC50 values of 0.113 μM, 0.476 μM, 3.136 μM, 3.649 μM, and 1.856 μM, respectively) . TTK-IN-5 potently suppresses tumor growth without notable toxicity in A2780 and MDA-MB-231 xenograft mouse models. TTK-IN-5 can be used for the research of cancer such as breast cancer and ovarian cancer[1].
UNSPSC
12352005
Target
Mps1
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Field of Research
Cancer
Smiles
COC1=CC=C(OC2=NC3=C(C4=CC(C)=C(C(NC5CC5)=O)C=C4)C=NN3C(N(C(C=C)=O)C)=C2)C(F)=C1F
Molecular Formula
C28H25F2N5O4
Molecular Weight
533.53
References & Citations
[1]JIANG C H, et al. Discovery and optimization of potent covalent threonine tyrosine kinase (TTK) inhibitors for the treatment of triple-negative breast cancer[J]. European Journal of Medicinal Chemistry, 2026, 302 (Part 1) :118271.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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