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DPP8/9-IN-2

CAT: 0804-HY-175226Size: 1 EachDry Ice: NoHazardous: No
CAT#: HY-175226Size: 1 Each
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AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DPP8/9-IN-2 (Compound 21) is a DPP8/9 inhibitor with IC50 values of 0.22 nM and 3 nM, respectively, and Ki values of 2.9 nM and 6 nM, respectively . DPP8/9-IN-2 has certain cardiotoxicity, with IC50 values of 0.7 μM, 29.0 μM and 27.7 μM for hERG potassium channel, Nav1.5 sodium channel and Cav1.2 calcium channel, respectively. DPP8/9-IN-2 can be used in the research of diseases such as tumors[1].
UNSPSC
12352005
Target
Calcium Channel; Dipeptidyl Peptidase; Potassium Channel; Sodium Channel
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(N1CC2=C(C=C(F)C=C2)C1)[C@@H](N)CC(N3CCC(C(C4=CC=C(F)C=C4)C5=CC=C(F)C=C5)CC3)=O
Molecular Formula
C30H30F3N3O2
Molecular Weight
521.57
References & Citations
[1]Nozal V, et al. Highly potent dipeptidyl peptidase 8/9 (DPP8/9) inhibitors designed via relative binding free energy calculations. Eur J Med Chem. 2025 Nov 5;297:117913.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DPP-8; DPP-9; Nav1.5

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