DPP9-IN-1

• Description :

  DPP9-IN-1 (Compound 42) is a dipeptidyl peptidase 9 (DPP9) inhibitor with IC50 of 3 nM for DPP9 and 0.6 μM for DPP8. DPP9-IN-1 induces concentration-dependent LDH release in THP-1 cells[1].

• UNSPSC :

  12352005

• Target :

  Dipeptidyl Peptidase

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Metabolic Disease; Neurological Disease

• Smiles :

  FC(C(F)=C1)=CC(C2)=C1CN2C(CN[C@@]3(C4)C[C@@H](C5)C[C@H]4C[C@]5(NC(OC(C)(C)C)=O)C3)=O

• Molecular Formula :

  C25H33F2N3O3

• Molecular Weight :

  461.54

• References & Citations :

  [1]Siham Benramdane, et al. Highly Selective Inhibitors of Dipeptidyl Peptidase 9 (DPP9) Derived from the Clinically Used DPP4-Inhibitor Vildagliptin. J Med Chem. 2023 Sep 28;66 (18) :12717-12738.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  DPP-8; DPP-9

• CAS Number :

  [3020859-03-1]